Production Equipment

Production Equipment

Through cooperation between our Research Department and Manufacturing Department, we are able to support multi-step production for orders ranging from several kilograms to several tons. With our multi-purpose equipment, we manufacture a wide range of high-quality APIs and intermediates through cGMP-compliant production and quality control.

Equipment at the Hirakata Plant

With the cooperation of the Research Department, we support sample work, pilot production, and high-mix, small-volume production to medium-scale production of commercial products.

Equipement Material Size Unit
Reactor GL 1,400~2,000 L 10
600~1,000 L 5
30~300 L 6
SUS 500 L~1,200 L 13
80 L 1
Autoclave reactor SUS 800 L (0.97 MPa) 1
Low-temperature reaction reactor SUS 1,000 L (-100℃~) 1
High-temperature reaction reactor SUS 620 L (~300℃) 1
Drying equipment Tray dryer SUS 300~500 L 7
Vacuum tray dryer SUS 200 L 1
Conical dryer GL 300~800 L 3
Centrifuge Top discharge type SUS 20~24 inch 12
Aflon lining 24 inch 2
Filtration equipment GL 50~100 L 2
SUS 10~110 L 10
SUS Columns 2
Pulverizing equipment Soft mill SUS 3
COMIL SUS 1
Feather mill SUS 1
Pin mill SUS 1
Clean room (CLASS 100,000)
Centrifuge Top discharge typeNEW SUS 24 inch 1
Drying equipment Tray dryerNEW SUS 500 L 1
Reaction equipment

Reaction equipment

Low-temperature reaction equipment (-80°C)

Low-temperature reaction equipment (-80°C)

Drying room

Drying room

Equipment at the Toyama Plant

We support large-volume production of pharmaceutical intermediates and active pharmaceutical ingredients including after midterm investigating and commercial products.

Equipement Material Size Unit
Reactor GL 8,000 L 1
2,000~5,000 L 26
100~500 L 3
SUS 1,500~5,000 L 13
300 L~1,000 L 5
Autoclave reactor GL 3,000 L (0.97 MPa) 2
800 L (0.97 MPa) 1
Low-temperature reaction reactor SUS 4,400 L(-100℃~) 1
High-temperature reaction reactor SUS 2,000 L (~300℃) 1
Drying equipment Air tray dryer SUS 1,000 L 3
Conical dryer GL 1,500 L 2
SUS 1,500 L 1
Centrifuge Top discharge type SUS 30~42 inch 8
Teflon 30 inch 2
Bottom discharge type SUS 24~36 inch 8
Filtration equipment GL 0.13~0.5 m² 5
SUS 0.13~1.26 m² 12
Pulverizing equipment Soft mill SUS 2
COMIL SUS 2
Victory mill SUS 1
Hammer mill SUS 1
Fine impact mill SUS 1
Clean room (CLASS 100,000 / 2 lines)
Reactor GL 4,000 L 1
Centrifuge Top discharge type SUS 30 inch 2
Drying equipment Air tray dryer SUS 600 L 2
Conical dryer GL 800 L / 1,500 L 2
Other
Pulverizing equipment, Sieving equipment, Centrifugal thin film vacuum evaporater, Ultrafiltration unit, Electrolyzer system
Reaction equipment

Reaction equipment

Conical dryer

Conical dryer

Clean room

Clean room

New BuildingNEW

We constructed a new building to improve production capacity in 2016. It complies with the current GMP and computer controlled systems are installed.

Equipement Material Size Unit
Reactor GL 10,000 L 1
8,000 L 1
5,000~6,000 L 5
SUS 800 / 2,000 L 2
Autoclave reactor GL 3,000 L(0.97 MPa) 2
Drying equipment Conical dryer GL 1,500 L / 2,000L 2
Centrifuge Top discharge type SUS 42 inch 1
HASTELLOY 42 inch 1
Bottom discharge type SUS 48 inch 1
Filtration equipment GL 0.12 m² 1
SUS 0.5 m² 1
10,000 L GL Reactor

10,000 L GL Reactor

HASTELLOY Centrifuge

HASTELLOY Centrifuge

Building appearance

Building appearance

Analytical equipment

Physical Methods

Chromatography

  • High-performance liquid chromatograph (HPLC)
  • Gas chromatograph (GC)
    Headspace sampling systemNEW

Spectroscopic Methods

  • Nuclear magnetic resonance spectrometer (FT-NMR)
  • Atomic absorption spectrophotometer
  • Inductively coupled plasma atomic emission spectrometry
  • Ultraviolet and visible spectrophotometers (UV/VIS)
  • Infrared spectrophotometer (FT-IR)

Other Physical Methods

  • Refractometer
  • Karl Fischer moisture titrator
  • Digital polarimeter
  • Potentiometric titrator
  • Conductivity meter
  • Differential thermal analysis and thermogravimetry equipment (DTA, TG)
  • Powder X-ray diffractometer
  • Total organic carbon analyzer (TOC)
  • Melting point apparatus
Powder property Determinations
  • Tap density determinator
  • Polarizing microscope, optical microscope,
  • Stereoscopic microscope
  • Laser diffraction particle size analyzer
  • Average particle size measurement apparatus
Microbial Tests
  • Toxinometer
  • Microbial testing apparatus
    (Clean bench, safety cabinet, autoclave, dry heat sterilizer, incubator)
Other
  • Stability testing chamber
Atomic absorption spectrophotometer

Atomic absorption spectrophotometer

High-performance liquid chromatograph (HPLC)

High-performance liquid chromatograph (HPLC)

Nuclear magnetic resonance spectrometer (FT-NMR)

Nuclear magnetic resonance spectrometer
(FT-NMR)

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